Word: kao
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...inaugural event. “This isn’t supposed to be a professional photography competition; it’s for students to share their experiences abroad,” DiMauro said. Although each photo had a story, some stories were more compelling for contest judge Deborah Martin-Kao, the Curator of Photography at the Fogg Art Museum. She found winning visions in four categories: landscape, sense of place and culture, people, and architecture. “I looked for photos that created a visceral sense of being in a place or worked against a stereotype...
...functions have changed (a mutated virus might no longer be infectious) and then work back and identify which gene mutated. If a mutated virus loses its ability to infect a cell, then that gene probably has something to do with infectivity. In chemical genetics, explains Dr. Richard Kao, the lead researcher on the HKU study, scientists try do the same by testing thousands upon thousands of chemicals on virus samples. The vast majority won't have any effect, but a handful will. Researchers can then take those virus samples and use further tests to figure out which viral gene...
...SARS study, Kao and his colleagues filled the tiny wells of a small, waffle-like board with samples of the coronavirus cultured in cell lines. Microscopic amounts of different chemical compounds were introduced into each separate well using a $180,000 machine called an automated high-throughput screening platform. Once the chemicals had time to interact with the virus, scientists could examine the results with an inverted microscope. The process was repeated until all 50,240 compounds in their chemical library had been tested, which took a few months. "You'd think it'd be tedious work...
...With help from their collaborators at the Aaron Diamond AIDS Research Center in New York, Kao and his colleagues discovered that one of 104 compounds inhibited a kind of viral processing inside the cell, six inhibited viral replication and 18 seemed to prevent the virus from entering the cell in the first place. (Kao says further work will be needed to figure out which viral genes the remaining 78 compounds affect. One of them seems to affect both processing and replication.) A number of these compounds could form the basis for promising anti-SARS drugs, and HKU plans to begin...
...that hanging over the show." But even if Father of the Pride bombs, Imagi has other projects in the works, including a movie for Japanese toymaker Bandai and a feature film of its own. "For this to work, you have to be wild," Kao tells his staff. "Give me some wild ideas." How about a young man who, weary of making Christmas trees with his dad, thinks show biz might be more...