Word: karp
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Dates: during 1960-1969
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...desperate moments began even before the controversial heart started pumping life back into Karp, 47, a printing estimator from Skokie, 111. Cooley warned Karp that if his badly damaged heart proved to be beyond repair, it might become necessary to use the experimental plastic device. Because the artificial heart is believed to cause serious damage to the blood if left in the body for too long, Cooley, along with Karp's family, issued a nationwide appeal for a human heart to replace it as quickly as possible. It was a starkly explicit appeal,calling for a person "with irreversible...
Even before Karp died, rumors began surfacing that the artificial heart (technically known as an orthotopic cardiac prosthesis) had been developed at least partially with funds assigned to a DeBakey research team and that it had been used without adequate testing and without DeBakey's knowledge or permission. The National Heart Institute has asked DeBakey and Cooley if federal funds were used in the development of the device. If so, said Dr. Theodore Cooper, NHI's director, its use was subject to federal guidelines covering human experimentation. He explained that these guidelines stipulate that "if experiments are going...
...survived for three days. Large-scale damage to the blood cells-one of the chief obstacles to the use of artificial hearts*-was cited as a contributing factor in the calves' deaths. Medical authorities, however, carefully refused to speculate whether any damage might have been done to Karp by similar "traumatization" of his blood cells...
Experience Needed. Cooley, for his part, remained unruffled. He claimed that the artificial heart used in Karp was developed entirely with funds from the Texas Heart Institute and other private sources. But he was cautious in appraising its usefulness. "We have demonstrated that a mechanical device will support the body," he declared after Karp's death. "But we've got to get more experience. It can only be used in a person who is at the brink of death or in a person who has already died, as, in effect, Mr. Karp had. He was completely dependent...
...long as a month with the artificial heart. When the question was repeated later in the week, however, his reply was more circumspect. "I don't know," he said. "This is a human being we're working with." As a result of the furor provoked by the Karp case and the still unresolved questions of procedure and ethics, heart surgeons are likely to be extremely hesitant before they try to duplicate Dr. Cooley's desperate...