Word: kaspar
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That study built on previous research by the Columbus-based team, which had successfully used gene therapy to treat rodents with the muscle-wasting disease muscular dystrophy. "We wanted to raise the bar and test a species closely related to humans," says neuroscientist Brian Kaspar, a co-leader of the study published in Science Translational Medicine. (Read "What Can Genetic Tests Tell...
...occurring protein follistatin, which blocks the function of another protein called myostatin that hinders muscle growth. Past research in mice that were genetically engineered to have an extra copy of the follistatin-producing gene has shown that blocking myostatin, by increasing follistatin, causes muscles to bulk up fast. What Kaspar and his team found was that the same effect could be achieved simply by injecting genes - ferried aboard a small, non-disease-causing virus known as AAV, or adeno-associated virus - into the muscle. They further discovered that once the gene was delivered into the muscle-cell nucleus, muscles began...
...1980s with All That Jazz. But critics would snipe that truly great films (and directors) were being overlooked: there would be no Cannes love for Rainer Werner Fassbinder (Ali: Fear Eats the Soul),Werner Herzog (Every Man for Himself and God Against All, aka The Enigma of Kaspar Hauser), Terence Malick (Days of Heaven) or Wim Wenders (Kings of the Road) - though it must be acknowledged that Wenders would eventually win in 1984 for Paris, Texas. Meanwhile, films from further afield were practically shut out by the Jury. Despite the Indian film industry's prodigious output, it was nearly impossible...
...keeps doing it, and keeps demanding nearly as much of his actors as of himself. He hypnotized the actors in Heart of Glass. He cast Bruno S., who had spent decades in mental institutions, as the star of The Enigma of Kaspar Hauser and Stroszek. When Nicholson backed out of Fitzcarraldo, Herzog got Jason Robards, who contracted amoebic dysentery and was forced to quit the shoot. (Mick Jagger, another member of the cast, also had to leave.) Herzog wound up with Klaus Kinski, an actor so extreme and unruly, he was his own volcano. They made five films together; Herzog...
...former colleague calls this part of Benedict's attempt to "simplify the papacy" and "deflate" the Pope's image in favor of his ideas. He expresses those ideas simply so that the author's style does not obscure the primacy of Christ. Observes Cardinal Kaspar: "John Paul would make longer, maybe more poetic discourses. Benedict is more precise. He is a theologian." An explainer of symbols, not the symbol itself...