Word: kevadon
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Dates: during 1962-1962
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DURING PREGNANCY. How narrow was the U.S. escape from the epidemic of malformed thalidomide babies became clear last week when Health, Education and Welfare Secretary Anthony Celebrezze announced that thalidomide (U.S. trade name: Kevadon) had been given to 15,900 U.S. patients, including 3,200 of child-bearing age, at least 207 of whom are known to have been pregnant. Most of the 207 women have had their babies, and apparently they did not take thalidomide in the second month of their pregnancies when it would have been harmful. As yet, no malformations have been reported...
...nonsense woman who has practiced medicine besides teaching pharmacology, was a new employee at FDA in September 1960. Her first major assignment was to pass on the application of Cincinnati's William S. Merrell Co. for a license to market thalidomide in the U.S. under the trade name Kevadon.* Along with the application came a sheaf of reports on years of animal testing and human use of the drug in Europe. There was no hint that the drug had any undesirable side effects, and Merrell pressed hard for quick approval. But Dr. Kelsey was puzzled because the drug...
Though Dr. Kelsey had kept Kevadon off the U.S. market for more than a year, this did not mean that no U.S. doctors were using the drug. (It was licensed in Canada, where at least 56 cases of deformed babies have been reported.) Last week Merrell reported that instead of the 100 or so U.S. physicians previously estimated to have got samples of the drug "for investigational use only," 1,231 had received Kevadon. How much of the drug each doctor got and used was unknown, so there was no way of estimating how many of the terrible blue tablets...
...Among foreign brand names: Kevadon (Canada), Distaval, Valgis, Tensival, Valgraine (Britain), Contergan, Grippex, Polygripan (Germany), Softenon (several countries...
...check every malformed birth since January 1959 in West Germany's most populous state (Nordrhein-Westfalen, 15.5 million people). Chemie Gruenenthal took Contergan. and every compound drug containing thalidomide off the market. And all 18,500 doctors in Canada got a December warning from the Merrell Co.: "Kevadon should not be administered to pregnant women nor to premenopausal women who may become pregnant." U.S. investigators using the drug got a similar warning...