Word: keys
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Dates: during 1990-1999
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...discovery has a multitude of practical implications. Cystic fibrosis, for example, and some forms of kidney disease are caused by the failure of key proteins to get where they ought to be. Understanding the details of such failures could probably lead to powerful treatments. Indeed, Blobel's research has already helped scientists use tiny cellular "factories" to mass-produce proteins such as erythropoietin, which stimulates red-blood-cell production. A deeper understanding of cellular machinery, which Blobel continues to pursue, could eventually show how cells are damaged in Alzheimer's disease, cancer and infections...
Beyond tradecraft, there is the larger question of why we would want to concentrate on just one school. "Sometimes, in order to tell a really big story," answers senior editor and key team member Nancy Gibbs, "we've found that it's best to look at it in miniature--in this case to spend a lot of time in one school and try to figure out what pressures it faces, what is working, what isn't and what has really changed since last spring, when we all discovered how complicated high schools can be." Allowed to peel back the layers...
...SMIT, a retired Colorado Springs homicide detective, worked on the case for 18 months before quitting in protest over the direction the probe was going. Smit formed another theory using key pieces of evidence. He believes the killer may have spotted JonBenet as she glided by in a convertible in Boulder's holiday Parade of Lights. On Christmas night, while the family was out, he entered through a basement window, roamed the house and penned a ransom note, using a legal pad and black Sharpie marker he found near the kitchen...
Although no suspects other than JOHN and PATSY RAMSEY have been named in the 1996 murder of their daughter JonBenet, a key figure in the investigation remains convinced that the killer was a pedophile bent on kidnapping who broke into the Boulder, Colo., home and assaulted the six-year-old while her family slept...
...there's a key difference between the two characters. Travis was, at the least, a sociopath; Frank, no less than the people he tries to help, is a victim. The movie is powered by his yearning not just for usefulness but also for transcendence. He hungers for peace, meaningful contact and someplace he can rest and heal from the nightly horrors he sees...