Word: kidney
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...intriguing but small study published in the New England Journal of Medicine, however, doctors at Massachusetts General Hospital and New York Presbyterian Hospital may have finally come up with an end run around organ rejection. They report on four kidney-transplant patients who were able to wean themselves off powerful antirejection drugs within a year of their transplants (a fifth rejected his kidney). Even more exciting is the fact that while the organ donors in the study were family members of the recipients, they were not perfect tissue matches...
...immune system's T cells, which normally patrol the body looking for foreign invaders like bacteria, viruses and tissues from outside donors. Several days before the transplant surgery, Sachs' team used drugs that target and eliminate these cells to wipe the immune slate clean. Then the team transplanted the kidney along with donor bone-marrow cells. What happened next was surprising: the bone marrow rebuilt the immune system but this time as a chimera?a hybrid of both the donated organ's cells and the body's own. The donated organ could then be accepted instead of rejected...
More perplexing to the team was the fact that the chimeric state is not permanent, with the immune system eventually returning to its original state. Yet the patients have nonetheless continued to tolerate their donated kidneys for almost five years. Why? Sachs believes that once the immune system is trained to accept the donated organ, sentry cells protect the organ from being recognized as foreign. The transplanted kidney exists in an immune bubble, guarded from the T cells that could still destroy...
...original version of this article mistakenly reported that surgeons transplanted a donated kidney along with bone-marrow cells that had been harvested from the patient. In fact, the bone-marrow cells also came from the donor...
...wealth percolated through the press. Citing declining health and diminished mental capacity, Suharto managed to stay out of court despite a 1998 legislative decree ordering an investigation in all corruption, collusion and nepotism charges involving Suharto. He was constantly in and out of hospitals after suffering strokes and undergoing kidney dialysis...