Word: kidneys
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DIED. GEORGE MIKAN, 80, pro basketball's first powerful big man, whose graceful, ambidextrous hook shots elevated the sport's profile during the 1940s and '50s and led the Minneapolis Lakers to five titles in the team's first six years; of kidney failure; in Scottsdale, Ariz. The 6-ft. 10-in. DePaul graduate so dominated the newly formed NBA that he forced the league to change its rules, expanding the 6-ft. "key" to thwart his offensive dominance, and once prompted Madison Square Garden officials to promote a 1949 game as "Geo. Mikan vs. Knicks...
Scientists initially became interested in the COX-2 enzyme because it's found in so many cancer cells. When active, COX-2 produces a chemical called a prostaglandin that helps keep the stomach lining healthy. It also helps the kidney and blood platelets function properly. In tumors, however, prostaglandin becomes a bad actor, an evil conspirator that helps build the new blood supplies that tumors need to grow. COX-2 also makes cancer cells more resistant to the body's immune response and more resistant to drugs. What would happen, scientists wondered, if you suppressed the COX-2 enzyme with...
...more effective today in prolonging survival than we were four years ago," says San Francisco's Volberding. Some potent antiviral substances are being tested, and several seem to stop or slow the reproduction of the AIDS virus at least temporarily. But they produce debilitating side effects, like kidney damage, which make them unsuitable for prolonged treatment. Among these drugs are HPA-23, a compound developed at the Pasteur Institute in Paris, where Rock Hudson sought treatment; Suramin, originally used to treat such parasitic disorders as African sleeping sickness; and Foscarnet, a drug being tested in Sweden and Canada...
...DIED. PRINCE RAINER III, 81, Europe's longest-reigning monarch, who, as ruler of Monaco for 56 years, transformed his tiny, nearly bankrupt principality into a tourist-friendly international business center; after a month-long hospitalization for heart, lung, and kidney ailments; in Monaco. With the help of his 1956 fairy-tale marriage to Hollywood royal Grace Kelly, Rainier modernized a community once called a "sunny place for shady people," building affordable hotels to draw middle-class visitors to its famed Monte Carlo casino, and popularizing the mini-state, which has no income tax, as a tax haven for foreign...
DIED. PRINCE RAINIER III, 81, Europe's longest-reigning monarch, who, as ruler of Monaco for 56 years, transformed his tiny, nearly bankrupt principalitya longtime gambling playground for Europe's wealthy éliteinto a tourist-friendly international business center; after a month-long hospitalization for heart, lung and kidney ailments; in Monaco. With the help of his 1956 fairy-tale marriage to Hollywood royal Grace Kelly, Rainier modernized a community once called a "sunny place for shady people," building affordable hotels to draw middle-class visitors to its famed Monte Carlo casino and popularizing the mini-state, which...