Word: knew
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...brain's "memory function" fails in the face of an insulin shortage. The group's prior research had already pinpointed the culprit: toxic proteins called amyloid beta-derived diffusible ligands (ADDLs, for short), which are known to pile up in the brains of people with Alzheimer's. Scientists also knew that Alzheimer's patients' brains have lower levels of insulin and are insulin resistant. But what the Northwestern team discovered is the molecular mechanism behind that resistance: when ADDLs bind to neurons at synapses, they obliterate the receptors that are normally reserved for insulin. Without those parking spaces...
...designer. In an all-black ensemble (except for a chic pair of snakeskin moccasins), the six-foot-one couture connoisseur exudes confidence. Within minutes of finding out the metropolitan theme of this year’s contest, Morton has formulated a vision for her project. “I knew I wanted to use newspaper from the get-go,” she explains. “I’m intrigued with the idea of found materials as opposed to going out and buying things.” Her first destination, therefore is no fancy textile outlet...
...played varsity lacrosse my senior year—I was the goalie,” she said. “I played with my twin sister, and my experience had a lot to do with her being on the team. It was our senior spring and we both knew we were going different places...
...heck of a football game, two really outstanding defenses playing well,” said Lafayette head coach Frank Tavani. “They do a very good job of disguising coverages,” Pizzotti said. “That’s something we knew all week. We had to be prepared for what they were going to show us and I think we did a good job of adjusting after the first couple of periods.” Both offenses benefited from the work of other units of the team: a blocked punt gave the Leopards possession...
...burst through the line and laid a big hit on DiPaola, who avoided a sack by making an ill-advised and wobbly throw that came up well short of the nearest receiver.“I started running after him, and as soon as I grabbed onto him, I knew he still had the ball, and then I kind of saw him throw it,” Dorris said. “I was thinking, ‘Dang, I didn’t get that sack,’ but then I saw Steve catch it and I thought...