Word: koprowski
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...oral vaccine, developed by Dr. Hilary Koprowski of Philadelphia's Wistar Institute, was made from weakened polio viruses grown in a culture of monkey kidney cells. Several monkey viruses have been known to contaminate such cultures, though vaccine makers now take pains to weed them out. Extrapolating from a number of coincidences -- the testing of the vaccine in the very site where AIDS is thought to have begun; Koprowski's recollection that he cultured the virus in the tissue of green monkeys, a species that harbors a virus similar to HIV -- writer Tom Curtis hypothesizes that the vaccine was contaminated...
...Czechoslovakia, Poland, Malaya, Singapore, and the U.S.S.R. Over ten million people were vaccinated in these countries, while in the Belgian Congo 2.2 million took another live virus vaccine, developed by Dr. Herald R. Cox of the Lederle Labs. Still a third live-type preparation was being developed by Dr. Koprowski of the Wistar Institute...
Import Later. Lederle officials, who have invested $13 million in developing the Cox product, were stunned by the PHS endorsement of Sabin vaccine, which was financed by March of Dimes funds and had the powerful support of the National Foundation. Also stunned was Dr. Hilary Koprowski, an early Lederle worker on the vaccine, now at Philadelphia's Wistar Institute. At issue was the question whether the Sabin vaccine was indeed safer than the Cox and Koprowski varieties, as the PHS implied...
...millions of oral vaccinations in a score of foreign countries to show that their vaccines are safe and sure.* But each insisted that his own was better than either of its two rivals. (Dr. Sabin has attacked the third vaccine, developed by the Wistar Institute's Dr. Hilary Koprowski, charging that it contains viruses that cause disease in monkeys and might be dangerous for man.) Dr. Sabin gives his vaccine in three separate doses a month apart-one for each main type of polio virus. Dr. Cox and colleagues give a single swig of trivalent vaccine...
South of the Border. Dr. Koprowski's Wistar version of live vaccine got its mass test in 215,000 subjects in the Belgian Congo and Ruanda (TIME, Aug. 11). Variants developed by Lederle Laboratories since he left are being widely used in Latin America...