Word: koprowski
(lookup in dictionary)
(lookup stats)
Dates: during 1950-1959
Sort By: most recent first
(reverse)
Leaders in perfecting live vaccines against polio have been the University of Cincinnati's Dr. Albert B. Sabin (TIME, May 23, 1955), and Dr. Hilary Koprowski. who began the work at Lederle Laboratories, then switched to Philadelphia's Wistar Institute. Dr. Sabin revisited his native Russia in 1956 to report on his early tests, so impressed Soviet medical men that they went to his Cincinnati labs for vaccine samples...
South of the Border. Dr. Koprowski's Wistar version of live vaccine got its mass test in 215,000 subjects in the Belgian Congo and Ruanda (TIME, Aug. 11). Variants developed by Lederle Laboratories since he left are being widely used in Latin America...
Moving spirit behind the test was Dr. Hilary Koprowski of Philadelphia's Wistar Institute. To combat epidemics of paralytic polio in the Belgian Congo, he got World Health Organization backing and Congo government funds, arranged a mass trial. Wistar Institute brewed big batches of two strains of polio virus: Chat (named from the initials of the child from whom it was taken), belonging to Type 1, and Fox III (named for a doctor who isolated it from a child victim), belonging to Type 3. Both strains were attenuated, i.e., they were grown in different media (including mice) until they...
Type 1 virus was causing most of the Congo's paralytic polio, Koprowski and colleagues found. They gave the Chat strain in capsules to 1,978 schoolchildren, found that none got sick, and all but two developed good antibody protection. It was exactly the same later with Fox III -all but two of the children responded well. The researchers were ready for a truly big-scale test...