Word: korff
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...dose of the medication originally prescribed: patients receiving the highest doses were nearly nine times more likely to overdose than patients on the lowest doses. "The overall risk among people who continued to use opioids was 0.25% per year [or two overdoses per 1,000 people]," says Michael Von Korff, a co-author of the study and senior investigator at the Group Health Research Institute in Seattle, adding that most people involved in the study were on low doses...
...misuse or suicide attempts, while others were due to patient error, but the study could not identify exactly what went wrong in all of the cases. Was it the high-prescribed dose alone, or were there other risk factors like illness, escalation of pain or undiagnosed addiction? While Von Korff and Volkow agree that prescription dose is a major contributor to overdose risk, they say better studies are needed to determine the precise causes and consequences. "One would hope that for a treatment regimen that millions of people are using, we'd have large, long-term, well-designed randomized controlled...
...while the risk of opioid addiction in the elderly is low, there are other cautions. A study published in January by Von Korff and colleagues linked high-dose opioid use to a doubling of the risk of broken bones in the elderly. "One-third of these were hip and pelvic fractures," Von Korff says. "These can really be debilitating." The authors speculate that the patients may have been prone to falls caused by dizziness or sedation, side effects of drug treatment that tend to occur early in a new drug regimen or when dosage changes...
...earnestness in the role of Harvey lent humorous believability to the appearance of absurd objects such as a purse filled with cooked oatmeal. Both directors and actors are to be commended for their ability to walk the fine line between zaniness and implausibility. Particularly arresting were Michael R. Von Korff ’07’s wacky performance as a madcap duck enthusiast in “Duck” and Ellen C. Quigley ’07’s mercurial shifts in emotional expression as the cagey, egotistical Jen in “The Lifeboat is Sinking...
Though von Korff said science fiction would always “to some extent be a fringe culture,” he maintained that Vericon has a broad appeal...