Word: kosterlitz
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...scientists wondered why the body developed opiate receptors in the first place, unless it somehow produces its own internal narcotics. Acting on just such a premise, Pharmacologists John Hughes and Hans Kosterlitz at Scotland's University of Aberdeen in 1975 isolated two peptides from the brains of pigs. Remarkably, the peptides seemed to be natural opiates. Hormonologist Choh Hao Li of the University of California in San Francisco had already discovered similar molecules in the pituitary glands of camels, animals whose insensitivity to pain had long intrigued scientists. Hughes and Kosterlitz dubbed the molecules enkephalins (from the Greek word...
Sharing the $15,000 prize were Dr. Hans Kosterlitz of the University of Aberdeen in Scotland, Pharmacologist John Hughes of the Imperial College of Science and Technology in London and Dr. Solomon Snyder of Baltimore's Johns Hopkins University...
...produce their effect. Morphine and similar drugs fit into these so-called opiate receptors like a key into a lock. Once in the lock, the drugs are able to dampen pain signals to the brain. Snyder then went on to map the distribution of the receptors in the brain. Kosterlitz and Hughes expanded on the research. They wondered why the body should evolve receptors for foreign narcotics; perhaps the body produced its own opiates. In 1975 they discovered and isolated two such compounds from pig brains and dubbed them enkephalins (from the Greek words for in the head...
...known role in physical pain but plays a major part in regulating the emotions, is unusually rich in opiate receptors. Thus variations in the number of receptors, or in the concentration of enkephalins?or the presence of narcotics?at these sites may affect emotions and behavior. Said Kosterlitz at the Manhattan award presentation: "The discovery of the enkephalins resembled the opening of Pandora's box, hopefully this time for the benefit of mankind...
...rest of that day she behaved in her usual introspective way. She went to bed and slept as usual, rose as usual. Next day she casually told her mother what she had done. Her mother drove Dema Dunlap to Dr. Kosterlitz, who refused to believe the young woman's story until he saw the projecting butt of the spike. He rushed her to a hospital where he extracted the nail. Then she fainted. There was some chance for her recovery, for a person can live with a large part of his brain gone. In Harvard's anatomical museum...