Word: krim
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...beginning, Arthur Krim, the United Artists studio boss who was also national finance chairman of the Democratic Party, was skeptical about this volatile blend of satire and surrealism -- until Frank Sinatra, the film's star, persuaded President John F. Kennedy to give his blessing to the project. Candidate opened in the fall of 1962, to mixed reviews and soft box office. "We had both sides of the political spectrum mad at us," says George Axelrod, who fashioned a terrific screenplay from Richard Condon's scathing comic apocalypse of a novel. "In Paris Communists picketed outside a theater on the Champs...
Even the most enthusiastic proponents of interferon concede that it is a difficult substance to work with, far more complex than traditional anticancer drugs. Just getting the dosages right can be tricky, and they are different * with each disease. "More is not better with the interferons," says Mathilde Krim of New York City's Memorial Sloan-Kettering Cancer Center. "Giving too much can have the opposite of the desired effect...
Some of interferon's failings may stem from the fact that it has been tried mainly in the most desperate cases of cancer, on those for whom no other treatment has worked. "These are the worst possible conditions in which to test it," says Krim. She and others think that interferon holds greater promise for patients with early cancers and those whose immune systems have not been weakened by radiation treatment or chemotherapy. Other potential uses for interferon: heading off the recurrence of tumors after they have been surgically removed, and preventing precancerous conditions like cervical dysplasia from progressing into...
...meeting did not start well. Walter Mondale, who had walked over from his hotel 15 minutes earlier, met his dogged challenger Gary Hart at the front door of the elegant Manhattan townhouse. The Colorado Senator, who had been up late, told Host Arthur Krim that he could use some coffee. "Your people said you'd want tea with your bacon and eggs," said Krim, a motion-picture executive. "That's the trouble with my campaign," replied Hart. "I like lots of coffee, and I don't eat eggs...
...Krim's four-story East Side residence was so mobbed by newsmen and TV technicians during the breakfast that police were forced to close the block to automobile traffic. As the closed meeting wore on, the mood outside grew slightly surreal; the two candidates' press secretaries, Maxine Isaacs and Kathy Bushkin, appeared on a second floor balcony at one point and tossed flowers to the crowd below. When Mondale and Hart finally emerged, they tried hard to convince their audience that the hatchet burying ritual had indeed been genuine. Said Hart, carefully using Mondale's nickname: "Fritz...