Word: kwak
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...protein, called an idiotype, that distinguishes them from their healthy counterparts. Mixing the idiotype with other substances that trigger immunological responses, "the vaccine presents a tumor protein to the patients in such a way that their immune systems recognize it and destroy any cells bearing that protein," explains Larry Kwak, associate director of Cancer Immunology Research at Houston's MD Anderson Cancer Center and a leading vaccine researcher...
...vaccine for follicular lymphoma is not new. Stanford University's Ron Levy pioneered the effort more than 25 years ago, demonstrating that anti-idiotype antibodies could be produced in a laboratory and used to create a vaccine for humans that would trigger an immune response. In 1999 Kwak, then working at the National Institutes of Health (nih), modified the vaccine in a way that makes it easier for the immune system to recognize. His results were striking: the vaccine eliminated the residual tumor cells left after chemotherapy in 15 of his 20 patients. Now Bendandi, who worked with Kwak...
...England Journal of Medicine, says, "Using patients as their own control is a bit shaky, especially for follicular lymphoma." A Phase III randomized trial, more difficult but still possible to conduct even with customized vaccines remains, he says, "the gold standard for proof of efficacy." Dr. Kwak, who is conducting his own Phase III trial of a vaccine for the American pharmaceutical company Biovest, believes his former trainee's results support the case for a therapeutic lymphoma vaccine, but is skeptical about his methods. "Dr. Bendandi's study is important because it confirms previously reported results. But taken in isolation...
...Kwak, a junior at Duke, is managing editor of the campus newspaper, The Chronicle...
...feel more at home.“An amazing amount of opportunity has opened up for me. I’m thinking about staying longer in the United States,” Marentis said.The other Harvard-affiliated Soros Fellows are Deema Arafah, Alvaro Bedoya, Amit Bouri, Susie Huang, Paul Kwak, Elizabeth Kwo, Darryl Li, Sze-Ling Ng, Antonio Perez, Yulia Ryzhik, and Colette Shen. The program has 172 alumni and 60 students currently participating...