Word: labs
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Dates: during 1990-1999
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...studio before recording their debut album, Garbage, in 1995. Their inexperience showed: while the album had its moments, it often felt indecisive and inorganic. In the past three years, Garbage has had a chance to tour, and now it sounds more like a band instead of a science-class lab experiment...
Christensen could have been bred in Dobson's lab. A Gingrich pet when he came to Congress as part of the blow-the-House-down freshman class of 1994, he was awarded a coveted seat on the Ways and Means committee. He announced his candidacy on the 25th anniversary of Roe v. Wade and got so choked up denouncing the decision that he had to stop speaking. He wants creationism to be taught at school after the kids say a prayer. He's for guns of every variety and promised never, ever to hire a gay person. But his personal...
When Dr. Judah Folkman is asked whether he can cure cancer, he invariably replies, "Yes, in mice." That's not entirely self-effacing whimsy. Like every good researcher--and every responsible science journalist--he knows all too well that most drugs that work in lab animals turn out to be duds in humans. The field is littered with "magic bullets" that failed, among them monoclonal antibodies, tumor necrosis factor, interferon and interleukin-2. While all were initially hyped as potential cure-alls, they have turned out to have only modest usefulness in the war on cancer. At best, says...
...with physical systems somewhat like our own, they give us a relatively quick, inexpensive way of getting at the causes of disease and possible therapies," says Dr. Kenneth Paigen, director of the Jackson Laboratory in Bar Harbor, Maine, the world's most famous mouse-breeding facility. Each year the lab ships out some 2 million mice from more than 1,700 stocks, including so-called designer mice with genes added or deleted so that they more closely "model" human disease. Among its customers is Folkman, whose lab relies on Jackson's best-selling C57BL/6J, or "Black 6" (cost...
Similar or not, no one, except perhaps a few animal-rights activists, is about to chase mice out of the lab. Mice save lives. Because their tumors develop almost overnight, says Merck's Oliff, "we can do tests 10 or 100 times more quickly than in humans." Their usefulness varies with diseases, though. He notes that rodents are better predictors of human reaction to cardiovascular or anti-inflammatory agents than to cancer or diseases of the central nervous system. But that's a trade-off researchers are more than willing to accept in their search for a cancer cure...