Word: labs
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Dates: during 2010-2019
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...that of his nearly 20-year-old facility, the Aaron Diamond AIDS Research Center (ADARC) in New York City, on his hunch. So is the Bill & Melinda Gates Foundation, which has steered nearly $7 million his way to pursue the theory. Ho has redirected more than half of his lab to the project, and the results so far have reignited his passion for discovery; he's now back at the lab bench overseeing experiments...
...first research centers dedicated solely to the study of AIDS, he led a team that pioneered the "hit 'em early and hit 'em hard" approach to drug therapy, now the core of the ARV-cocktail treatment that is keeping millions of HIV-positive patients alive. His lab showed how HIV therapies would be most effective in the days and weeks immediately after HIV infected a new host. That understanding came from their breakthrough finding that rather than sitting latent for years after infection, as many experts believed at the time, HIV was actively challenging the immune system from...
...ADARC was a great experience," says one, who now heads an immunology lab at a major university. "Those were really great times, and you don't experience them often in an academic career. The structure put in place for the first few years was magnificent and very collegial. But unfortunately the happy ending didn't go forth...
...malaise at the lab, which Ho attributes to personality conflicts among the faculty, began to infect the quality of the science. In 2002, Ho generated headlines when he thought he had found the X factor made by immune cells that protected some people from developing AIDS. It turned out, however, that his conclusion was premature. Other cells had contaminated his results, and he was forced to issue a "retraction of an interpretation" of the paper describing the study. "It was an embarrassing moment for us, but we fixed it ourselves," says Ho. "It was certainly a low point...
...didn't even wait to leave the meeting before phoning his lab with instructions to investigate the literature on ibalizumab. "He was so excited about it," says Yaoxing Huang, who received the call and is now one of the two researchers Ho has diverted to investigating the compound. Barely three years later, that initial enthusiasm has only grown, spreading throughout the labs that occupy two floors at ADARC's Lower East Side facility...