Word: lak
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Dates: during 1980-1989
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Rosenberg is working on a new and potentially more powerful therapy called TILs, for tumor-infiltrating lymphocytes. In tests on mice, he notes, these cells appear "50 to 100 times more potent than LAK." TILs are actually killer T cells that, like LAK cells, can attack cancer cells. To produce them, researchers expose malignant cells removed from the patient to IL-2. The tissue includes killer T cells that have launched a weak attack; with a sharp boost from the IL-2, they replicate and proceed to destroy the cancer. A month later, the newly potent T cells, vastly increased...
...factor or interleukins, for example. Last year, in one of immunotherapy's most promising clinical trials to date, Rosenberg's team used the hormone-like substance interleukin-2 to turn certain white blood cells into cancer destroyers called lymphokine- activated killers. Reinjected into the bloodstream with more IL-2, LAK cells shrank or eliminated tumors in several patients. As news of the experiment spread, desperate cancer victims around the country besieged the NCI for LAK treatment. Able to take only a handful of patients, the institute is still turning away hundreds each week. Nearly overlooked in the news reports...
...cells, as if by instinct, sought out the tumors that had spread from the original cancer and attacked them. To keep the TIL cells vigorous and growing, the NCI team had to inject the mice with additional IL-2, but only about a tenth as much as in the LAK treatments. As a result, few serious side effects were apparent. With the addition of cyclophosphamide, a drug that Rosenberg believes suppresses immune-system cells that might otherwise impede the TIL cells, the treatment achieved its spectacular success rates. Most important, the combined therapy cured mice of advanced colon cancers that...
...Instead it is a rite of commercial nostalgia: Beehive, two hours of songs from girl singers and girl groups of the '60s. Six wailing women, six guys in the house band, the stage a huge steel blue jukebox. Plus 32 wigs, 25 costume changes and 15 cans of Aero Lak hair spray each week. "Our wig designer spends so much time hair spraying," says Larry Gallagher, 35, the show's creator and director, "he has to wear a surgical mask." But that is the only extravagance. Beehive offers no frills, few risks -- just a sweet wallow in the bottomless pool...
...offers a generous amnesty program. So far this year more than 1,000 guerrillas in the northeast have defected. Those who defect are not asked to apologize or recant. They are generally given work on government construction projects or assisted with funds gathered by local merchants. Says Lieut. General Lak Salikupt, regional commander of the Second Army: "Persuasion is always more efficient than gunfire...