Word: lanza
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Dates: during 2000-2009
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Still, the rapid pace of the research means we may not have to wait long. "We really lucked out," says Lanza. "These iPS cells were just discovered a few years ago, and here we are three years later with a method safe enough to actually use in people." ACT plans to file a request for the first human trial using its cells sometime next year...
...Robert Lanza, chief scientific officer at Advanced Cell Technology (ACT), reported today in the journal Cell that his team has created stem cells using human skin cells and four proteins. The innovation builds on the breakthrough discovery in 2006 by Shinya Yamanaka, who similarly coaxed human skin cells to revert to a pristine, embryonic state by introducing four key genes into the cells, piggybacked on viruses. However, some of those genes are known to cause cancer, which made Yamanaka's stem cells - known as induced pluripotent stem cells, or iPS cells - unsuitable for human use. (See a graphic explaining...
Until now, no one has been able to create iPS cells without using viruses and genes. But Lanza and his team found a way around both: the researchers isolated the proteins made by the same genes Yamanaka used and "tagged" them with a message that allowed the proteins to slip easily into the cell. Yamanaka's method, on the other hand, relied on using viruses to ferry genes into the skin cell...
While the new iPS cells may be safer, even Lanza admits there is much that researchers still need to learn about how they will react once inside a patient's body. The most pressing question remains whether iPS cells - or the nerves, muscles or any of the 200 other types of tissues potentially generated from them - would act the same way as human embryonic stem cells, which were not created in a petri dish. "We don't know if iPS cells can do everything that normal human embryonic stem cells can do," says Lanza. "There are certainly...
...their living room. Like their spotless carpet and the shiny flat-screen TV, the couple possess a pristine appearance in “The Pain and the Itch,” which runs until April 4th at the Boston Center for the Arts. But as Clay and Kelly (Joe Lanza and Aimee Doherty) tell their guest (Cedric Lilly) the story of a strange Thanksgiving that begins and ends with the mysterious bites in their avocados, it becomes apparent that there is not just one monster and not just one painful itch in their outwardly perfect lives. While the play?...