Word: ldl
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Dates: during 2000-2009
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...some of the lost weight, and after two years, average weight loss was about 9 lb. Only about 15% of participants were able to lose 10% of their body weight or more. Across the board, however, patients lowered their risk of diabetes and reduced blood levels of bad cholesterol (LDL) while increasing good cholesterol (HDL) and overall heart health...
...Archives of Internal Medicine, scientists at Tel Aviv University found that patients taking statins for up to five years reduced their risk of death from any cause by 45%, compared with those not taking statins. Granted, most of the people who benefited had high levels of LDL cholesterol, the "bad" cholesterol, to start, so they were more likely than others to be helped by the drugs' ability to prevent plaque build-up in artery walls. But many patients also had never had a heart attack or other heart event. That means statins may have helped stave off such an event...
...that's the case, it would add to the growing list of statins' unexpected benefits. Initially the drugs were designed to inhibit the liver's ability to make cholesterol, but it turned out that they not only lowered LDL, but raised levels of HDL, or good cholesterol, in the blood as well. In the early 2000s, researchers reported that statins also reduced inflammation, a process that appears to contribute to the rupture of unstable plaques in the heart vessels, which triggers heart attack...
...older, who had high levels of C-reactive protein (CRP) but normal cholesterol levels and no history of heart disease. Half the participants were given rosuvastatin (Crestor), and half were given a placebo daily for just under two years. The statin group reduced their CRP levels by 37%; their LDL, or bad cholesterol, levels dropped 50% to about 55 mg/dL. Among the 8,901 statin-takers, 31 suffered a heart attack and 33 suffered a stroke. When compared with the placebo group, those figures translated to a 54% lower risk of heart attack and a 48% lower risk of stroke...
Although JUPITER (Justification for the Use of Statins in the Prevention: an Intervention Trial Evaluating Rosuvastatin) was designed to study inflammation, its findings also underscore the risk of high cholesterol. The study's statin group clearly benefited from reducing CRP, but they had also simultaneously lowered their LDL levels to nearly 50% below the government-prescribed target of 100 mg/dL. Experts say the JUPITER results may prompt serious rethinking of the current guidelines - an issue that health officials have already been debating in recent years. "I would not be surprised if, given these results, we determined that normal LDL should...