Word: ldl
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...have a professional and a personal interest in statins, the cholesterol-lowering drugs that so many people are taking these days. Whereas I don't have a history of heart disease, it runs in my family. Although I exercise regularly and watch what I eat, my LDL (or "bad") cholesterol level has always been a bit elevated (it hovers around 100, which is right at the limit recommended by the U.S. government). So I followed with particular interest the results of the first head-to-head comparison of two of the most popular statins: Lipitor (made by Pfizer) and Pravachol...
ApoA-1 Milano eventually became the property of Esperion Therapeutics, in Ann Arbor, Mich., which persuaded Nissen to conduct the studies that led to last week's report. If the results hold up in larger trials, they could be revolutionary. Statin drugs, which lower the bad LDL cholesterol that causes plaque in the first place, reduce the risk of dying from heart disease only 30% or so. By targeting HDL as well, the risk might be halved. Says Nissen: "We're starting to talk about really limiting what this disease...
...pediatrician Dr. Denes Molnar, fully 9% of obese children and adolescents already suffer from a premorbid condition known as metabolic syndrome. Among the most worrisome symptoms are changes in blood chemistry that can trigger future health problems. A substantial fraction of chubby kids, for example, have elevated levels of LDL cholesterol, putting them at risk for atherosclerosis. Many also have elevated blood-sugar levels, a precursor of Type 2 diabetes. Around the world, the prevalence of Type 2 diabetes, formerly known as adult-onset diabetes, is soaring in the under-18 crowd. As a result, complications like nerve...
Statins, the cholesterol-lowering wonder drugs, are getting a lot of press these days. And, to be sure, they can save lives by dramatically lowering blood levels of LDL, the "bad" cholesterol. But statin drugs are expensive and work only as long as you keep taking them. Also, they can have side effects and should not be taken by people with liver problems...
...results? The low-fat diet reduced LDL cholesterol levels 8%. The same diet with lovastatin reduced cholesterol 31%. The fiber-and sterol-rich diet reduced cholesterol levels 29%--almost the same amount. The magnitude of the reduction is what is so encouraging, says lead author Dr. David Jenkins. "These are food components that research over 25 years has established as having cholesterol-lowering properties," he explains. "What we didn't know, but have now shown, is that their effect is actually additive...