Word: leadings
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...actually very active in our lives every day, regulating how various cells in our bodies behave. In the brain this can be especially powerful. Any significant experience triggers changes in brain genes that produce proteins - those necessary to help memories form, for example. But, says the study's lead author, Ian Maze, a doctoral student at Mount Sinai School of Medicine, "when you give an animal a single dose of cocaine, you start to have genes aberrantly turn on and off in a strange pattern that we are still trying to figure...
...human study, of course - and an even bigger leap to consider developing a G9a-based treatment for addiction. The protein regulates so many genes that such a drug would almost certainly have unwanted and potentially deadly side effects. But a better understanding of the G9a pathways could lead to the development of safer, more specific drugs. And studying the genes that control G9a itself could also help screen people at risk for cocaine addiction: those with naturally lower levels of the protein would be the ones to watch. Still, there's a lot to be learned even from further mouse...
...These were people in the problem-drinker category," says lead researcher John Cunningham, senior scientist with the Canadian Center on Addiction & Mental Health. He explained that before they used the website, subjects were typically consuming 22 alcoholic drinks per week. "They drink enough to risk health consequences but are not severely dependent...
...This is a step towards identifying specific adaptations that have risen as humans expanded and faced new environments,” said Shari R. Grossman ’08, the lead author of the paper...
...years, scientists have sought to differentiate mutations that actually lead to selective change in a population from mutations that simply arise by chance. But current methods can only identify large stretches of genome as potential selection markers, according to Grossman...