Word: leans
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Dates: during 1990-1999
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...major reason for obesity in people, most experts concur. But that does not mean leptin might not be therapeutically useful for many other overweight people. In last week's Science, for example, a team of researchers from the pharmaceutical company Hoffmann-LaRoche described how they plumped up lean mice by giving them unrestricted access to high-fat food. Then they administered leptin. The mice responded by cutting their food intake and shedding the extra ounces, suggesting leptin may have value in reversing more typical cases of weight gain...
What about side effects? Injections of leptin do not, as one might fear, turn lean mice into starving wretches. After losing weight, researchers from Amgen reported, normal mice stabilize both their food intake and their metabolism. Obese mice likewise reach an optimal leanness, then stop losing weight. The pattern of weight loss is also encouraging. For unlike extreme calorie restriction, which can weaken muscle, leptin appears to dissolve fat while leaving lean tissue intact. On the basis of such data, Amgen (which paid Rockefeller University $20 million for patent rights to make products based on the ob gene) has announced...
...Burger for 17 years as Chief Justice of the United States never really disguised the fact that underneath he was an exuberant prairie yeoman--and proud of it. After a few sips of one of his fine clarets, Burger, who died last week at the age of 87, would lean back and reminisce about his rearing in the mold of the Horatio Alger stories, where young boys never rested, tried everything, excelled at much and took joy at each simple turn in a life on the land. He recalled the hot summer workdays near St. Paul, Minnesota, when he would...
...seller in a seller's market; the studios want his clients and will pay hugely for them. As MCA czar, he would have been a buyer in that market. The fellow who helped jack up the price of the product would now be asked to run a lean, mean company. It's like putting the mice in charge of the pantry...
...entertainment world, Harvard and Radcliffe Class of 1970 graduates are few, but their contributions are significant. There is an Emmy award-winning actress, a producer/manager of multiple Tony award-winning Broadway shows including "The Secret Garden," the producer of the films "Lean on Me" and "Colors," an actress from the popular Fox network television show "Beverly Hills 90210" and the musical orchestrator for the Walt Disney animated films "Beauty and the Beast," "Aladdin" and the soon-to-be-released "Pocahontas...