Word: leans
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...conclude that Buchanan has, in one sense, already won. When Bob Dole denounces Hollywood sleazemongers, when Phil Gramm's pollster tells him to talk more about "fair trade, not free trade," when Arlen Specter starts to peddle a flat tax and Lamar Alexander blasts congressional pensions, Buchanan gets to lean back in the rented van that drives through the north country of New Hampshire and revel in remaking the Republican Party in his own image. This has become the Buchanan Effect. "All the candidates are responding to it," he notes with satisfaction. "These moderate Republicans...
...triumphant Bolshevism. Scorn for tyrants is etched on many of the pre-World War II Berlin stories, as well as others written during the '40s and '50s after he immigrated to the U.S. And woe to the poseur whose influence is based solely on personality. From Spring in Fialta: "Lean and arrogant, with some poisonous pun ever ready to fork out and quiver at you, and with a strange look of expectancy in his dull brown veiled eyes, this false wag had, I daresay, an irresistible effect on small rodents...
...Legion and the University of Hertfordshire, where he studies literature. The two men, both British, carry green fatigues in waterproof bags. They have short haircuts. Whiting, burly, with a broken nose, speaks fluent rough-and-tumble French that he learned in the legion while serving on Mururoa. Baker, a lean, hard mountain climber with a seen-better, seen-worse expression, speaks nothing but rich, working-class Sussex. Someone says, "Cheers," Baker revs the outboard and the little inflatable, low in the water, rocks away on the swell, towing the kayaks toward Mururoa. The air is still, and for 10 minutes...
...major reason for obesity in people, most experts concur. But that does not mean leptin might not be therapeutically useful for many other overweight people. In last week's Science, for example, a team of researchers from the pharmaceutical company Hoffmann-LaRoche described how they plumped up lean mice by giving them unrestricted access to high-fat food. Then they administered leptin. The mice responded by cutting their food intake and shedding the extra ounces, suggesting leptin may have value in reversing more typical cases of weight gain...
What about side effects? Injections of leptin do not, as one might fear, turn lean mice into starving wretches. After losing weight, researchers from Amgen reported, normal mice stabilize both their food intake and their metabolism. Obese mice likewise reach an optimal leanness, then stop losing weight. The pattern of weight loss is also encouraging. For unlike extreme calorie restriction, which can weaken muscle, leptin appears to dissolve fat while leaving lean tissue intact. On the basis of such data, Amgen (which paid Rockefeller University $20 million for patent rights to make products based on the ob gene) has announced...