Word: leschly
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Dates: during 1960-1969
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...patients' enzyme systems. But what? Although it was easy to show that victims had an excess of uric acid in their blood, the metabolic pathways by which it got there remained hidden in the biochemical jungle. Then in Baltimore, Pediatrician William L. Nyhan Jr. and Dr. Michael Lesch saw two retarded brothers with the palsy and biting symptoms. It has since been learned that a substance was missing from their blood: an enzyme forbiddingly named hypo-xanthine-guanine phosphoribosyltrans-ferase, or PRT in the trade...
...Family. By now, 80 victims of the Lesch-Nyhan syndrome have been identified. Very few have survived beyond puberty; most are in institutions. All are boys, indicating that the enzyme defect is transmitted, like hemophilia, through the mother on an X chromosome, although she appears unaffected. Researchers at the National Institute of Arthritis and Metabolic Diseases checked to see whether the same enzyme deficiency could explain typical adult gout. It does in only a few cases, they reported last week. In one family, two gout victims have only about 1% of the normal PRT; in another family, it is about...
Search for Food. Since Lesch became president in 1960, Colgate has introduced such successful new products as Baggies plastic bags, Halo hair spray, Ajax detergent powder, and half a dozen others th#t now account for 15% of its annual sales of $800 million. Colgate is testing freeze-dry foods with a view to jumping into the food field, is searching to acquire a food company. This week, battling to regain the top of the U.S. toothpaste market that it lost to Procter & Gamble's Crest, it began national marketing of a white-colored, mint-tasting, fluoridated toothpaste called...
...burst of activity in a company whose U.S. sales had been stagnant for years until Lesch took over, is what might be expected of Mr. Hard Sell. An accountant who rose through the international division, which rings up 53% of the company's sales, Lesch has personally rung doorbells to interview housewives from Bangkok to San Diego, has sold Colgate's Fab to Mexican villagers by rolling up his sleeves to show them that they could even use it to wash clothes in streams. His first act as Colgate president was to drop out of sight for three...
Executives Out. Lesch set up a number of "invention groups," increased the annual product-development budget from $8,000,000 to $28 million-and helped to pay the bill by cutting the salaried force by 10% to 15%. Some critical ex-executives complain that under Lesch, Colgate's middle managers are overworked and insecure, and that the company's profits have yet to top the 1959 record of $25 million. At the same time, Lesch gets credit from the trade for having brought out so many new products with catchy names and clever promotions-two of the essentials...