Word: lessing
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...test that theory, the researchers conducted a series of experiments, the most illuminating of which revealed that when the TLR5-deficient mice were given unrestricted diets, they ate 10% more than normal mice, and that even when their food was limited, they were still less sensitive to insulin than their normal counterparts...
When that happens, the study found, it triggers an inflammatory state, as the body attempts to respond to the increasing population of bugs, and at the same time makes cells less sensitive to insulin. In a way, inflammatory factors and insulin compete for the attention of the same intestinal cells; if the cells are busy responding to inflammatory factors, then they are less likely to take up glucose and process it effectively. Such a desensitization to insulin and glucose then leads to the symptoms of metabolic syndrome, such as weight gain, high cholesterol and triglyceride levels and elevated blood pressure...
...type and amount of microbes that reside in the intestines. In the current study, scientists found that in TLR5-deficient animals, the total percentage of 150 species of bacteria in the gut was three to four times higher than in normal mice, while 125 other types of bacteria were less common. "We don't have a sense of which is more important yet - that some of those species are missing, or that some are in greater abundance," he says. The net effect, however, is that in the absence of TLR5, the community of microbes changes and, as Gewirtz says, "when...
...observational study, participants who regularly used ibuprofen were 40 percent less likely to develop Parkinson’s disease over a six-year period, according to lead researcher Xiang Gao, an instructor in medicine at HSPH...
Hispanic and African American mothers were more likely to be overweight when pregnant, and their children more likely to be born small, gain excess weight over time, get less sleep, and begin eating solid food sooner, the researchers found...