Word: leukemias
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Dates: during 1970-1979
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...them off to his daughter (Barbara Parkins), who responds with pronounced interest. Naturally, Alda's frau (Jacqueline Bisset) doesn't at all care for the lavish attentions of Jurgens and his kinky retinue of friends, but Alda is too flattered to listen. When Jurgens suddenly dies of leukemia, Alda, who has resumed his musical career, takes over the master's concert dates and an incestuous love affair with Parkins. His wife, in the meantime, has stumbled on some evidence (a book of incantations, a flask of mysterious blue oil, more or less the usual things) that strongly...
...with Temin's discovery was at first believed to be unique to cancer cells infected by viruses. Thus when Columbia University's Sol Spiegelman and the National Cancer Institute's Robert Gallo found high enzyme activity in the cells of leukemic patients, medical science had a solid clue that leukemia might be caused by a virus. Even more important, some researchers speculated that if the Temin enzyme was found only in cancer cells, the spread of cancer might be halted simply by inhibiting the enzyme...
...considers safe for the general population, Joshua Lederberg, Nobel Laureate in genetics, estimates a 10 per cent increase in the mutation rate. Other researchers, notably Drs. Gofman and Tamplin of the AEC, estimate between 32,000 and 150,000 additional annual deaths due to increased mutation, cancer and leukemia...
Carefully examining the white blood cells of 48 healthy people and three leukemia patients, Gallo and two colleagues−Stringner S. Yang and Robert C. Ting of the Bionetics Research Laboratories−discovered a small but possibly critical difference. The white cells of the leukemia victims showed the presence of an enzyme known as RNA-dependent DNA polymerase; the cells of the normal people did not. The presence of the enzyme suggested that it may play a key role in the development of the disease...
...detecting the enzyme in human leukemia cells−something that has also been done by Spiegelman's team−the scientists may have discovered an important diagnostic tool. Testing for the presence of the enzyme may now help doctors to identify leukemia in its earliest stages. And early identification is almost always the first step toward a cure. If the enzyme is proved to be at the heart of the process resulting in leukemia, it should be possible to find chemicals that suppress...