Word: leukemias
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Dates: during 1990-1999
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...researchers had never confirmed that the children of exposed men could be affected. Earlier this year, researchers in England reported that such transmission may in fact be possible. Children of male workers at the Sellafield nuclear power plant were up to eight times as likely to be stricken by leukemia as children whose fathers did not work at the plant. The researchers theorized that cumulative low-level doses of radiation during the six months before conception may have triggered the damage...
...some of which appear to be more important than others in human cancers. Mutations in the RAS oncogene, for instance, are believed to play a role in a majority of pancreatic and colon cancers, and some lung cancers as well. Mutations in other oncogenes have been linked to leukemia and the most lethal forms of breast and ovarian cancer...
...adoptive parents of an 18-year-old Korean man are searching the Korean community at Harvard this weekend to find potential bone marrow donors to help their son in his fight against leukemia...
Extracting viable T cells from their young patient, Anderson and Blaese exposed them to mouse leukemia retro-viruses into which human ADA genes had been spliced. The retroviruses, rendered harmless by genetic engineering, were the vectors, the vehicles that would deliver the genes to their target. They invaded the T cells and, as retroviruses are wont to do, burrowed into the T- cell DNA, carrying the ADA gene with them. Finally, a billion or so T cells, now equipped with ADA genes and floating in the gray solution suspended above the little girl's bed in Bethesda, were dripped into...
...strategy, devised with the help of Anderson, is to extract immune cells called tumor-infiltrating lymphocytes (TILs) from the tumors of melanoma patients. Rosenberg bathes the TILs in a solution of interleukin-2, a natural substance that invigorates them, and then exposes the TILs to re- engineered mouse leukemia retroviruses...