Word: lifespan
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...rapamycin delayed the deaths of the longest-lived male mice by 101 days and by 151 days in the longest-lived females - the equivalent of about 13 years on average in humans - compared with mice with no treatment. In terms of life expectancy when treatment began (or average remaining lifespan when the mice were 600 days old), that translates to an increase of 38% in female mice and 28% in males...
...also prolonged life in lab mice. But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species." It may guide researchers to target different proteins in the same pathway. "If those proteins react the same way to extend lifespan, then we might be able to get rid of unwanted side effects," says Strong...
...beginning to change. At Carnegie Mellon, for instance, psychologist Sheldon Cohen has been exploring exactly how positive emotions affect the body. (This is the flip side of previous work by Cohen and others linking stress, Type-A behavior and negative emotions to lowered immunity, heart disease and shorter lifespan.) Cohen's research shows that people with a "positive emotional style" have better immunity to cold and influenza viruses when exposed in the lab. His most recent work, presented at the conference, suggests that this is mainly due to the release of optimal levels of cytokines, proteins that regulate the immune...
Cohen and his colleagues have also been studying how social relationships and positive emotions can impact lifespan. Their work builds on a famous 2001 University of Kentucky study of aging nuns, which found that the more positive emotions the nuns had expressed in brief autobiographies written 60 years earlier at age 22, the longer they lived. In an interesting twist on that study, Cohen and colleague Sarah Pressman similarly analyzed a collection of autobiographies - this time, written by 96 leading psychologists at an average age of 65. Once again, there was a correlation between longevity and positive emotions...
Thuras and Foer say they've both been surprised by the reception they've gotten during the site's short lifespan; high traffic forced them to beef up their server in the first week the site went live. Thuras says it's hard to say exactly why Atlas Obscura resonates with travelers, who have flocked in droves to contribute new places to the site. "I think as the world gets smaller, people are still excited to see that there's lots still to discover - and that there's still a lot of weird stuff out there," he says. The hope...