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...expected those opportunities to come so soon. Trying to discover the right combination of genes that would reprogram adult cells was a scientific fishing expedition in a deep ocean. In early 2004 Yamanaka had worked up a list of 24 possible genes he thought were instrumental in cell programming, and was ready to begin testing them. There was no guarantee any of the 24 suspects were the right ones, and when Yamanaka offered the experiment to one of his students, the researcher turned him down. "We knew the chance that the correct answer was in those 24 factors was very...

Author: /time Magazine | Title: Ahead of the Curve | 6/14/2007 | See Source »

Just in time for swimsuit season, GlaxoSmithKline (GSK) launches ALLI (pronounced ally), the first weight-loss drug available without a prescription. Alli is the over-the-counter version of Xenical, a drug best known for its list of unpleasant side effects, which include "oily discharge" and loose stools. To fight the intense criticism that overzealous dieters--particularly younger ones--will abuse the drug, GSK's extensive education campaign includes a book of recipes and free pedometers to remind dieters that no pill works alone...

Author: /time Magazine | Title: Dashboard: Jun. 25, 2007 | 6/14/2007 | See Source »

...many ways, that wouldn't be such a bad thing. Coney Island has fallen long and hard from its apex in the early 20th century, when its grandiose rides and spectacles--it once featured a Lilliputian village populated with 300 midgets--were a must-see, even for A-list tourists like Charles Lindbergh and Sigmund Freud, who supposedly declared Coney Island the only part of America that interested him. In the decades that followed, TV and air travel provided other options for escape, as parts of the neighborhood were razed for public housing. Revival-minded artists have partly displaced...

Author: /time Magazine | Title: Postcard: Coney Island | 6/14/2007 | See Source »

...leads to the payoff, when an agent tells the breathless owners, "I would list your house for ..." It may not be realistic (how certain can an appraiser be that a half-bath is worth exactly $20,000?). But it's brilliant TV, allowing us to indulge a little jealousy (say, of the lucky bastard who bought a Manhattan apartment for $90,000 in 1990) and vicarious money lust. And it demonstrates how the housing boom changed the way people look at their homes: as an expression of their financial savvy rather than their creative selves...

Author: /time Magazine | Title: Home Economics on TV | 6/14/2007 | See Source »

...Senator John Thune, a South Dakota Republican who also opposed the measure last week, said he might be convinced to support the measure if his amendment - which would prioritize the securing of U.S. borders before giving any benefits to undocumented immigrants living in the U.S. - is included on the list of those to be considered. Bush "was very persuasive, very rational," Thune said. "He presented a coherent argument about why he thinks this is the right thing to do without getting all pushy...

Author: /time Magazine | Title: Bush's Last-Ditch Plea on Immigration | 6/12/2007 | See Source »

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