Word: livered
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Dates: during 1990-1999
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...harder to get a liver or heart transplant in Maryland than it is in Kansas? Maybe not, but you?d probably get that impression from a new Health and Human Services report. The study charts the rates of death while waiting for a transplant, the chances of getting a new organ and the percentage of successful procedures associated with heart and liver transplants in 100 medical centers across the country. The numbers, picked up ahead of time by the Associated Press, are being released Thursday but are causing an early stir in the medical establishment. According to the report, there...
...nerve pain, including that often accompanying cancer and AIDS. Better yet, this class of drugs has a low level of side effects. Drowsiness, dizziness, nausea and unsteadiness, if they do occur, can usually be alleviated by adjusting the dosages of the drug, while more severe side effects, such as liver toxicity, blood disorders and disturbed vision, are relatively rare...
Jesse Gelsinger, 18, had good reasons not to sign up for experimental gene therapy. Though the Tucson, Ariz., teen was born with a rare genetic disorder that partly disabled his liver, his course of drugs and diet was working. The Phase I trial at the University of Pennsylvania, where doctors would pump a modified cold virus into his system to correct genetic flaws, promised nothing in the way of a cure...
...undergoing some 230 clinical trials. Since viruses are so good at hacking into the human body, scientists figure they can be used as packaging material for whatever gene the patient lacks. In Jesse's study, all 18 participants had the same disease: ornithine transcarbamoylase (OTC) deficiency, which slows the liver's ability to metabolize nitrogen and releases deadly ammonia into the bloodstream. So Wilson's team harnessed the adenovirus (a cause of the common cold), neutralized harmful elements and used the virus to send in normal copies of the gene that was defective in Jesse...
What is still puzzling is why Jesse's body reacted so violently. Was his an isolated case, or is there a problem with the way this virus was delivered--injected into the bloodstream? Is it a safe technique? Is the liver too sensitive? Should this particular kind of gene-therapy research be stopped altogether...