Word: livers
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Dates: during 1980-1989
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...person eats too many saturated fats, however, liver cells suppress the production of LDL receptors. Cholesterol then collects in artery walls in plaques, the hallmark of atherosclerosis. Conversely, a low-cholesterol diet stimulates the output of new receptors, thereby preventing heart disease...
...normal and can suffer heart attacks as early as age two. By comparing skin cells from victims with those of healthy people, the two scientists traced the problem to an absence or deficiency of LDL receptors, proteins that stud the outer membranes of most cells, particularly those of the liver. Then they decoded the complex minuet that takes place between the receptor and its LDL particle. Says Baltimore: "That was important for understanding how cells communicate with their environment...
Although cholesterol is popularly regarded as an enemy, the body needs it to manufacture new cell membranes, steroid hormones and bile acids. Made primarily in the liver and also obtained through food, cholesterol travels through the bloodstream in round bundles of fat and protein called lipoproteins. Like Venus's-flytraps, vacant LDL receptors snare the passing packets. The lipoproteins are rapidly broken down in the cell, and the cholesterol is freed for use, while the receptor returns to the membrane, ready for prey...
...terrible stomach and bladder problems." Leistner has four children, all in their 20s. "One of my daughters has a seizure disorder; she tried to commit suicide in 1983. Another daughter, she's hyperthyroid; we almost lost her to cancer of the cervix at 21. My former husband has a liver impairment...
...strap. As I did so, the skin fell away, and the dry white bones of the rib cage appeared. Beneath the ribs, living within the body of the horse, moved a massive snake. Its skin shone green and blue. It was bloated and overfed; full of the heart, the liver, and the intestines of my perfect horse, my symbol of purity. It moved within the body of the horse in a circle...