Word: livers
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...substantial portion of drugs taken orally, in pill or liquid form, is lost to digestive processes and removed by the liver, and what remains can irritate the intestinal tract. Enter transdermal patches. First designed to treat motion sickness, they slowly deliver drugs through the skin from a reservoir within the patch, and are being used increasingly to treat hypertension, angina and other disorders. So far, the patches are limited to carrying small-molecule drugs that can diffuse through the skin. But several teams are experimenting with electrical or ultrasonic devices that can also push larger-molecule drugs through the skin...
...envisioned. Last year the company reported results of a clinical trial in which Onyx-015 injections, in combination with chemotherapy, melted away tumors in eight out of 30 patients with recurrent, late-stage head and neck cancer. In another study involving 27 patients whose cancers had metastasized to the liver (a condition that usually kills in six months), 11 were still alive nearly two years after being treated with a high dose of Onyx...
...halting that process, including some old-line drugs that have turned out to have anti-angiogenic properties. Thalidomide, which caused devastating birth defects in some 12,000 children worldwide before it was withdrawn in the early 1960s, is finding a new lease on life against multiple myeloma and liver cancers. Pharmaceutical giant Bristol-Myers Squibb is testing an antiangiogenic drug that was initially developed to keep cancer from worming its way into surrounding tissue. It’s also investigating whether low, steady doses of traditional chemotherapy may be able to beat back blood vessels, a treatment that would have...
HEPATITIS HOPE Hepatitis C, which afflicts 3 million Americans, is becoming the leading cause of liver cancer and cirrhosis. Today's treatment? Mostly interferon, which is not always effective and has notoriously discomforting side effects like fever, chills, aches and pains. Researchers have developed a modified form of interferon called Pegasys that can be taken once a week instead of three times and has fewer, milder and more transient side effects. Best of all, Pegasys is two to five times as effective. FDA approval is expected soon...
...Boris Yeltsin's liver b) His own hairline c) Any hope that Russia will one day be economically sound d) The old Soviet national anthem...