Word: locks
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...terms of rejections, but fellowships, grant applications, grad school admissions and recruiting are just as bad for the psuche, if not worse. Here we are, having put in four more years of hard work and dedication and monetary investment, only to find that every door has its own lock which our expensive and highly-prized set of Keys won't necessarily open...
...plausible enough: if one knows the precise three-dimensional structure of an enzyme target, one can use a computer to design a perfectly complementary "small molecule drug" to jam into the enzyme and disable it, just as a locksmith can build a key from scratch to open a lock...
Vertex scientists solved the structure in 1992 (see picture below) and began to explore several potential sites for artificial blockage, using supercomputers to suggest possible "keys" for the HIV "lock." In practice, the computer's guess is often far from perfect, but computers can help bench-top scientists refine their search for the molecule with the perfect...
...person with the gold puts the pot into his box. He locks it, but keeps his key. He sends it over with the boatman. The other one then puts his lock on the box and keeps his key. Then he sends it back to the first person. Then the first person removes his lock and sends it back to his friend. The second person unlocks the box, opens it and revels in his newfound wealth...
...from spring break that D. was summoned to trial one fine morning. Noticing that her mailbox was full, she smiled with delight at the thought of the countless J. Crew catalogues eagerly awaiting her perusal. D. finally managed to pry open the mailbox after running through several dozen possible lock combinations (having forgotten hers), only to be bitterly disappointed by the usual array of phone bills and overdue library fines. Just as she was about to throw the vast majority of the pile away, however, she noticed an envelope emblazoned with the words "JURY DUTY: YOUR CIVIC RESPONSIBILITY." The date...