Word: low
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Dates: during 1980-1989
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Michael Bruno of Cincinnati is one heart-disease patient who has benefited from drug therapy. A 55-year-old former printing-plant foreman, Michael and his brother Daniel, 58, a retired barber in Canonsburg, Pa., have a genetic disorder that results in very high levels of LDL and low levels of HDL. Daniel has suffered a heart attack, and both brothers have had bypass surgery. Now the Brunos are on low-saturated-fat diets and are taking lovastatin. In addition, Michael is taking gemfibrozil. Since the brothers started their programs, Michael's total cholesterol has fallen from...
...Research Institute, is that there is no absolute proof that raising HDL alone can lower a person's risk of heart disease. No convincing body of evidence from animal studies has yet demonstrated the value of raising HDL, and no clinical trial to date has specifically targeted humans with low HDL. "Much the same question existed for LDL until this decade, when it was unequivocally shown that lowering LDL decreases the risk," says Levy. The situation is similar with HDL today, he says, "except that with HDL we have not been smart enough yet to set up clinical trials designed...
...element in an alphabet soup of particles that make up the so-called lipid transport system, which moves cholesterol through the bloodstream. Though individual cells can make their own cholesterol, much of their supply comes from the bloodstream, arriving from the liver aboard macromolecular ferryboats, known as very-low-density lipoproteins, or VLDLs. These carrier particles are loaded in the liver with cholesterol and dietary fats known as triglycerides, which are used by cells for energy or stored for future...
...reverse the buildup of plaque? There are indications that this may be the case. Last year Dr. David Blankenhorn, director of atherosclerosis research at the University of Southern California, reported on a study in which 162 nonsmoking men who had undergone coronary- bypass surgery were put on a low-fat diet; 80 of them were also treated with niacin and colestipol. Among the drug-treated group, HDL levels increased 37%, while LDL decreased 43% and triglycerides went down 22%. Blankenhorn found evidence that arterial disease had been halted in 61% of the drug- treated patients, compared with 39% who were...
...curiosity to such subjects as Asian-American students, the environment and the hospice movement. In preparation for this week's stories, Brand so immersed himself in the subject that he even had his own cholesterol count checked. He was relieved to find it was 170, well within the low-risk range. But that should have come as no surprise. A self-described "food fanatic," Brand avoids cholesterol-rich dishes and relaxes by preparing Chinese meals that are low in saturated fats. He credits his diet sense to the influence of his wife Sandra, a former registered nurse who works...