Word: low
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...even if you, like the mouse, are low in RbAp48, don't pin all the blame for your memory loss on your hippocampus. As people get older, their attention starts to flicker, and that plays a role of its own. The prefrontal cortex, which controls planning, organization, abstraction and forethought, is the same region that allows us to concentrate, and it starts to diminish in size well before middle age. It also begins to use the brain's fuel, glucose, less efficiently and loses about half the neurotransmitter dopamine it once had. The result of all this, says Amy Arnsten...
...neurotrophic factor (BDNF), a protein that stimulates the birth of new brain cells and then helps them differentiate and connect. BDNF also enhances neural plasticity, the process by which the brain changes in response to learning. In diseases like Alzheimer's, depression, Parkinson's and dementia, BDNF levels are low. In people who exercise, BDNF levels rise...
...other hand, my cynical low-information political brain was saying, You go, girl. This was fun to watch. "This is a serious election," Clinton said in Gastonia, "but I believe you still should have some fun." She seemed energized by her irresponsibility, sprung from her lifelong, eat-your-peas policy straitjacket. She had always been the superego of Team Clinton; now she was gallivanting about, playing the id. It seemed like smart politics too. It was the kind of thing I have seen "work" throughout my nearly 40-year career as a journalist, an era that coincided neatly with...
...Politics will always be propelled by grease, hot air and showmanship, but in the astonishing prosperity of the late 20th century, we allowed our public life to drift toward too much show biz, too little substance. Yes, the low-information signals - the bowling and tamale-eating - are crucial; politicians have to show that they are in touch with the lives of average folks. But a balance needs to be struck between carnival populism and the higher demands of democracy, and as a nation, we haven't been very good lately with the serious part of the program. As a result...
...from Arizona won the Republican nomination in much the same way Obama has triumphed - as an outsider, an occasional reformer, a pariah to blowhards like Limbaugh. But it's also true that McCain has a choice to make: in the past month, he has wobbled between the high and low roads, at one point calling Obama the Hamas candidate for President after a member of that group "endorsed" the Senator from Illinois. If McCain wants to maintain his reputation as a politician more honorable than most, he's going to have to stop the sleaze. And if Obama wants...