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...January, when most of Attorney General Eric Holder's friends and enemies turned against his plan to try 9/11 mastermind Khalid Sheikh Mohammed in a federal courthouse in lower Manhattan, one man stood by him. And he was a good friend to have. At a Situation Room session on Jan. 29, Holder was virtually alone in arguing for sticking with a civilian trial for KSM. A Manhattan jury, he said, would produce a quick conviction - and that image would help restore America's reputation in the world. When others in the room argued in favor of military tribunals with special...
Segal was one of 24 million people taking drugs to lower cholesterol in the U.S. that year. The workhorse of American medicine, statins - first sold in the U.S. in 1987 and marketed under brand names like Lipitor, Zocor and Crestor - are designed to clear away LDL cholesterol, the waxy buildup that can clog arteries and trigger heart attacks and strokes. Doctors say the majority of current statin users are healthy people who don't have heart disease but who, like Segal, simply have high cholesterol. Use among this group, known as the primary prevention population, has made these drugs...
Other researchers say that evidence is muddy. The reduction in cardiovascular events sounds impressive until you take a closer look. Men taking Crestor had a lower risk of hard events, including fatal and nonfatal heart attack and stroke. But the only statistically significant benefits for women treated with Crestor involved less extreme end points, like hospitalization for unstable chest pain and arterial revascularization (a category of procedures that includes major surgery). To prevent one event, 36 women would need to take the statin for five years - a modest result, critics...
...Risk Profile, StupidWhy statins fail to show equal benefits for men and women is unclear, but one reason may be that women are simply at lower risk of heart disease than men. You would need a powerful treatment to lower an already low risk. Researchers also don't know why women are more likely than men to suffer side effects from statins and many other drugs but posit that lower body weight and hormonal fluctuations play a role. Biological explanations aside, the larger point is the same: with any treatment, the benefits should outweigh the risks...
...decreased cost can largely be attributed to lower interest rates on the debt used to finance construction in the wake of the financial crisis, according to Construction and Project Manager Mark R. Johnson...