Word: lunges
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Dates: during 1990-1999
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...sarcoma, the cancer in which it was first discovered). In about 30% of cancers, the RAS protein is stuck in an "on" position, mindlessly ordering the cell to divide again and again. It plays a role in 90% of pancreatic cancers, 50% of colon cancers and 25% of lung cancers. Dr. Edward Scolnick discovered the RAS gene in rats while working at the National Cancer Institute in 1978. Now president of Merck Research Laboratories, he is overseeing the development of a drug that stops the RAS protein from sending its malignant message. Several other big drug companies, including Bristol-Myers...
...common cancer gene: one that codes for a protein called the EGF (epidermal growth factor) receptor. This receptor, which takes in growth signals and relays them to the RAS protein, is found in abnormally high numbers on the surface of about 40% of tumor cells, including about 90% of lung-cancer tumors, some prostate tumors and other malignancies. Researchers at M.D. Anderson Cancer Center in Houston are testing an antibody to EGF receptors in patients with advanced head and neck cancers. But most other groups, including teams at drug makers Pfizer, Novartis and Zeneca, are using smaller molecules that, unlike...
...Memorial Sloan-Kettering Cancer Center in New York City, Dr. Mark Malkin is working with a substance that targets a receptor for another growth factor called PDGF (platelet-derived growth factor). This receptor studs the surfaces of cells in certain ovarian, prostate, lung and brain tumors. Malkin has been testing the drug, SU101, on patients with an extraordinarily deadly brain tumor called glioblastoma. Median survival for a patient found to have this cancer is 14 months...
...promise of these drugs holds up, however, cancer treatment in the 21st century will bear little resemblance to today's chemotherapy. Drugs will be precisely tailored to the individual tumor, and the cancers themselves will be described not by the site they attack--breast cancers, lung cancers, etc.--but by the genes they express. The National Cancer Institute is at work creating a DNA library of tumor types, a long-range project called C-GAP (Cancer Genome Anatomy Project). But it will be years before this library can be put to practical use. "It took 20 years to make testing...
DIED. EDDIE RABBITT, 56, rangy country singer who, despite all his down-homey hits--among them I Love a Rainy Night and Drivin' My Life Away--was the Brooklyn-born son of Irish immigrants; after battling lung cancer; in Nashville, Tenn...