Word: lupus
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Dates: during 2000-2009
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...different challenge. Since HGS was founded in 1992 by scientist William Haseltine, the company has not taken a single drug to market. It's a good thing Watkins is an accomplished manager of late-stage drug development. Aside from shepherding HGS's candidate drugs for cancer and lupus through clinical trials, Watkins hopes to license out potential drugs to other pharmaceutical companies to help build a revenue stream for HGS, which lost $185 million last year.--By Unmesh Kher
Some of that resilience may be linked to human leukocyte antigen (HLA) genes, a group clustered on chromosome 6 that affects vulnerability to such autoimmune diseases as lupus, rheumatoid arthritis and multiple sclerosis. Centenarians living in Okinawa, for example, have variants of HLA that tend to protect against those diseases. Perls has found a region on chromosome 4 that centenarians and their siblings and children in the U.S. seem to have in common and that sets them apart from shorter-lived individuals. The finding has not yet been replicated by other groups, but Perls expects to publish a paper...
When the Body Attacks Itself No doctors have more experience treating chronic inflammation than the physicians who specialize in rheumatoid arthritis, multiple sclerosis, lupus and other autoimmune disorders. For decades these diseases have provided the clearest example of a body at war with itself. But the spark that fuels their internal destruction doesn't come from excess cholesterol deposits or a stubborn bacterial infection. Instead, in a bizarre twist of fate, the body's supersophisticated, learned immunological defenses mistakenly direct an inflammatory attack against healthy cells in such places as the joints, nerves and connective tissue...
...What about longer-term effects when the silicone migrates beyond its capsule? No scientific studies have proven a connection between the implants and diseases like rheumatoid arthritis and lupus, but critics complain that the research hasn't been adequate, or over a long enough time period. Government-funded studies on immune responses following silicone implant leakage or rupture is ongoing, and many women swear there's a cause-and-effect relationship. Mary McDonough, who underwent breast augmentation to help her transition from being a young star of "The Waltons" to other film and television work, became progressively sicker with lupus...
...carelessly dumped by the giant utility, Pacific Gas & Electric, and seeped into the groundwater used by the town's residents. In bringing suit against PG&E, Brockovich's law firm charged that chromium-6, in addition to causing cancer, was responsible for disorders ranging from rashes and nosebleeds to lupus, miscarriage and Crohn's Disease in 600 of Hinkley's residents. The case eventually went to arbitration, and a panel of judges awarded residents a settlement of $333 million dollars, 40 percent of which went to the lawyers. For her efforts Brockovich received a two million dollar bonus...