Word: lupus
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...Storey Mountain, was a best seller in 1948), fathered a child out of wedlock before taking his vows; later, as a middle-aged hermit with a taste for bourbon, he had a brief love affair with a nurse. Walker Percy drank too much. Poor Flannery O'Connor, crippled by lupus, dead at 39, sometimes sounded alarmingly like a racial bigot...
...Omega-3s prevent platelets in the blood from clumping together and sticking to arterial walls in the form of plaque. They also drive down triglycerides and LDL (bad) cholesterol. Researchers suspect that omega-3s may block the production of inflammatory substances linked to autoimmune diseases like rheumatoid arthritis and lupus. Even more tantalizing, preliminary reports suggest that omega-3s interact with the fatty layers that surround brain cells and, as fishy as it sounds, may somehow help protect brain cells from the diseases of aging, like Alzheimer's. Other sources of omega-3s: herring, mackerel and bluefish...
...scientific exploration and a talent for directing researchers toward practical and profitable products. By investigating the genes most relevant to pharmaceutical research, HUMAN GENOME SCIENCES is transforming itself into the world's first genomics-based pharmaceutical behemoth. It already has six drugs in clinical trials, for diseases including lupus, colitis and several chemotherapy- induced ailments. Haseltine's approach to decoding the genome promises to bring biotech's benefits more quickly to patients and shareholders alike...
That story, in fact, has inspired trials of nearly two dozen new biotech medicines. IDEC Pharmaceuticals in San Diego, for example, has zeroed in on the interactions between CD4 T cells and APCS to make antibody drugs against lupus and RA. The company's anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has a drug that blocks Interleukin-1, another molecule that promotes inflammation...
Thanks to technologies spawned by genomics, the list of potential drug targets is growing rapidly. Human Genome Sciences and Seattle-based ZymoGenetics, for instance, are independently developing drugs to inhibit a newly discovered factor that stimulates B cells and is produced copiously in RA and lupus patients...