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...Georges Mathé, a leading cancer researcher at the Paul Brousse Hospital at Villejuif, near Paris, has been using BCG since 1964. He administers it as part of a double-barreled approach to treating patients with acute lymphoid leukemia, a cancer of the blood-forming tissues that tends to further depress and obliterate the patient's already weakened immune responses. Mathé begins with chemotherapy, using cell-destroying drugs that kill rapidly proliferating cells (and thus destroy cancer cells more quickly than normal ones) to reduce the size of cancers from billions of cells to 100,000 or so. Then he uses...

Author: /time Magazine | Title: Toward Cancer Control | 3/19/1973 | See Source »

...detailed workings of the immune mechanism are still imperfectly understood, but the main outlines are clear. The principal components of immunity are a type of white blood cell, the lymphoid cells. They have the genetically built-in ability to identify other cells as "self" (part of the same body) or "not self" (invaders to be destroyed). In the presence of "self" cells the lymphoid cells remain passive, but if they detect foreign material, they manufacture antibodies to contain or attack the invader. These antibodies are in the form of gamma globulin particles. Some remain on the surface of the lymphoid...

Author: /time Magazine | Title: Transplants: Why Blaiberg Died | 8/29/1969 | See Source »

...what farmers call "big-liver disease" in chickens. Ten years ago, Dr. Davis developed cancer in her lymphatic system, and had heavy radiation treatment. She compared cells from her own tumors with those from chickens. Said Dr. Davis, with scientific detachment: "They were very closely comparable microscopically to the lymphoid chicken tumors with which I had been working...

Author: /time Magazine | Title: Cancer: From Fowl to Woman? | 4/3/1964 | See Source »

...Miller therefore studied the growth of the mice operated on at birth. He found that their spleens were only half normal size, and that most of the lymphoid tissues (in which protective white cells are made) were badly degenerated...

Author: /time Magazine | Title: Medicine: Secrets of the Thymus | 2/23/1962 | See Source »

...belt extending almost around the world (from East Pacific islands to southeast Asia, equatorial Africa, northeast coast of South America, and up to the Caribbean islands), 189,000,000 people have filariasis, which causes swelling in the lymphoid tissues. About 20,000,000 people have oncocerciasis, which causes blindness when the worms get into the eyes. A new antimony compound called Neostibosan has proved effective against filariasis, and another new drug, hetrazan, against oncocerciasis...

Author: /time Magazine | Title: Medicine: Polluted Reservoir | 5/24/1948 | See Source »

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