Word: lymphomas
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...establish a general cause and effect relationship between viruses and cancer. Recent advances in the field of genetic engineering have paralleled a surge of interest in the possibility of a genetic cause of cancer. But apart from circumstancial evidence for genetic causes of such rare cancers as Burkitt's lymphoma (as Harvard recently announced), the possibility of finding such a genetic cause for all cancers seems remote...
...isolated a virus that can transform normal human white blood cells into the malignant type found in a rare cancer called T-cell leukemia. The same virus was found last year to be responsible for a relatively high rate of both T-cell leukemia and a form of lymphoma (cancer of the lymphatic system) in Japan. Says Gallo: "There is strong evidence that this virus will be important for a number of human cancers...
...decades that certain forms of cancer are associated with certain visible changes in the 23 pairs of chromosomes found in human cells. Recent studies suggest, for example, that in some lung cancers a piece is often missing from chromosome No. 3. Better-documented changes occur in certain leukemias and lymphomas. In one form of chronic leukemia, a piece of chromosome 22 changes place with a piece of chromosome 9. In most patients with a cancer known as Burkitt's lymphoma, a piece of chromosome 8 has changed places with a piece...
...these "translocations" might cause cancer has never been known, but the first real insight was announced at the Chicago conference. Researchers representing teams at Harvard and at Philadelphia's Wistar Institute reported that they had analyzed the piece of chromosome 8 involved in Burkitt's lymphoma. Both found that it contained a gene virtually identical to a cancer-causing gene isolated years earlier from a virus. The oncogene is located at the precise point where the fragment of chromosome 8 broke off. Thus the first link has been made between a known oncogene and an easily detectable change...
...Saturday, Oct. 20,1 went to Camp David. There I received a "supersensitive" memorandum from Deputy Secretary of State Warren Christopher. He reported, "We have now learned the Shah's illness is malignant lymphoma compounded by a possible internal blockage that has resulted in severe jaundice. The lymphoma responded satisfactorily when chemotherapy was started several months ago, but recently the chemotherapy has been less effective. The Shah has not had tests necessary to establish proper diagnosis and further chemotherapeutic approaches. Dr. Benjamin Kean of the Cornell Medical School, who last saw the Shah yesterday, has advised us that these...