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...funded trial called Sequenced Treatment Alternatives to Relieve Depression, which usually goes by the moniker STAR*D. The STAR*D project, which collected data from 2001 to 2004 at 41 U.S. psychiatric facilities, was one of the most ambitious efforts ever to understand how best to treat people with major depression. STAR*D participants comprise a powerful research sample because they are highly representative of all depressed Americans. Very few depressed people were excluded from STAR*D; only women who were pregnant, those with seizure disorders and a few others with acute conditions were kept out. All other psychiatric...
...bolster their findings, the authors cite a smaller 2002 study that arrived at similar results: in that paper, published in the American Journal of Psychiatry, Dr. Mark Zimmerman of Brown University and his colleagues found that of 315 patients with major depressive disorder who sought care, only 29, or 9.2%, met typical criteria for an efficacy trial. Similarly, psychologist Ronald Kessler of Harvard co-authored a 2003 paper in the Journal of the American Medical Association that concluded that most "real world" patients with major depression would be excluded from clinical trials because of comorbidities...
When it comes to opera, big is traditionally beautiful. But London's English National Opera (ENO) - the small, scrappy neighbor of the illustrious Royal Opera House - has succeeded by going a different route. While major opera houses bank on grand sets and virtuosos projecting stiffly from center stage, the ENO's nimble productions are as intimate as the form permits. "We want to draw our audience in rather than draw their attention to the artifice of what they are watching," says artistic director John Berry...
...Although the leaders spoke at the summit about how their pact would boost annual commerce between Canada and the E.U. by around $27 billion, they were also contemplating that the seal ban could lead to a major trade tiff. Canada has already promised to challenge the ban at the World Trade Organization - and stands a good chance of overturning it, since WTO rules only allow prohibitions based on health and safety...
...buried within the Parliament ban is a recognition that seals often have to be hunted to ensure the sustainability of fisheries in some areas. Indeed, the population of seals on Canada's east coast is now 6 million, three times what it was in the 1970s, making them a major threat to fish stocks. (See TIME's Pictures of the Week...