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Vertex's first major research effort--designing a safe and reliable inhibitor for the HIV protease that assists with the replication of the HIV virus--started with generating a molecular map of the protease enzyme...
...crystallography allows us to map out the atom-by-atom three-dimensional structure of a drug target, [especially] the active site," says Brum. "The more precise information we can have about the active site helps us to develop a safer, more potent drug...
...parent's possession of firearms and failure to keep them away from their kids, it's easier to connect that to a subsequent criminal act by the child. It's more concrete." Florida passed the first CAP law in 1989, and 14 other states have enacted similar legislation (see map). CAP laws are pending in Massachusetts, Illinois, New York, Missouri and South Carolina. In Connecticut, California and Florida, violation is a felony. In Florida adults can face five years in prison and a $5,000 fine if a minor obtains a firearm and uses it to inflict injury or death...
Lowell, Massachusetts. D. had earlier noted this fact, and upon consulting a map, had discovered that Lowell, Massachusetts was located vaguely near the New Hampshire border. Glancing at the summons again, D. was suddenly inspired by the line reading "HARDSHIP: In a hardship situation, you may request to serve in a different court from the one to which you were assigned." D. had a thought--a rare event indeed...
...shifted control over welfare spendingfrom the federal government to state legislatures.From Honolulu to Augusta, states equipped with ageneral road map from Washington have blazed theirown paths in reforming welfare...