Word: maraviroc
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...Pfizer's maraviroc, one of the two new compounds described this week, steps in just after HIV has successfully bound to a healthy cell; called an entry inhibitor, it blocks the virus from entering the cell and integrating its viral genetic material into the host cell's genome. In a study of more than 1000 patients who had developed resistance to at least three of the four ARV classes, twice the number of patients given maraviroc versus those taking placebo enjoyed undetectable levels of virus after eight months. The results were enough to convince Pfizer to apply for approval...
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