Word: markered
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...least 10% -- and perhaps as many as 70% -- of Alzheimer's cases are inherited, the researchers began analyzing the DNA from four large families that had one thing in common: a history of the disease stretching back over many generations. After three years of work, they isolated two genetic markers, or molecular signposts, on chromosome 21 that are located close to the still unknown gene responsible for the inherited form of the disease. "The identification of these markers overcomes a major hurdle," says M.G.H. Neurogeneticist James Gusella, who directed the research. "This is the first step toward the identification...
...that wasn't the case with the other two acts on the bill. Brian Kiley, a local comic, clearly wants to be a Steven Wright with personality. Some of his lines are gems--like the one about the blind and deaf person who reads lips with a yellow-highlighting marker. But he was too much of a Brian-two-note--varying incessantly and to no great effect on such tired themes as polyester leisure seats and mobile homes--and couldn't capture the audience. Master of Ceremonies Brett Butler tried hard, but was undistinguished. Many of her lines were...
...grader. The true master of a generality is the man who can write a 10-page essay, which means nothing at all to him, and have it mean a great deal to anyone who reads it. The generality writer banks on the knowledge possessed by the grader, hoping the marker will read things into his essay...
Like a runner trained for long distances, America's economic expansion is showing remarkable staying power, if not robust speed. The U.S. recovery, which passed the four-year marker in November, just keeps chugging ahead in spite of ever present doubts and dangers along the road. Since its start in 1982, the expansion has been refreshed at crucial intervals, first by the plunge of interest rates and later by the fall of oil prices. Now, at 49 months and counting, the durable recovery is already the second longest peacetime boom in U.S. history, after the 58-month expansion...
...UCSD team quickly realized that the successful harnessing of luciferase might yield other benefits. If the firefly gene was a simple, straightforward and easily manipulated one-gene-one-enzyme system (some enzymes require the cooperative efforts of several genes), it might be possible to use it as a $ marker, or "reporter," gene. "We lucked out," says Helinski. "It did turn out to be a single gene that we could manipulate...