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...schizophrenics, of course, that only made their condition worse. But researchers soon realized it made their pill perfect for patients with depression. On first trying it in 1955, some patients found themselves newly sociable and energetic and called the drug a "miracle cure." The drug, called imipramine and marketed as Tofranil in 1958, was quickly followed by dozens of rivals - known as tricyclics for their three-ring chemical structure - as drug companies rushed to take advantage of a burgeoning market. (See the top 10 medical breakthroughs...
...patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs provided relief for the same percentage of patients...
...When it comes to pain and cold medicine, this may be particularly worrisome. Tylenol, NyQuil and other drugs that contain acetaminophen are among the best-selling meds on the market, with more than $2.6 billion in sales in the U.S. in 2008. But acetaminophen can also put stress on the liver. From 1990 to 1998, there were an estimated 56,000 emergency-room visits, 26,000 hospitalizations and 458 deaths related to acetaminophen overdoses, according to the Food and Drug Administration (FDA). These figures include everything from attempted suicides to people who gulped down entire bottles trying to get well...
During the trial, Gertner recognized an "interregnum period," when listeners had no way of purchasing digital media legally before the advent of the iTunes Music Store in 2003. She noted that during this period, "unauthorized use" should be considered "more fair" since there was not yet a ready market in which users could pay for the files...
...Read "The Job Market: Is a College Degree Worth Less...