Word: marmorston
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...five years on Premarin, the corresponding death rates were 7% and 27%. But dosage is critical. Dr. Stamler warned against giving Premarin within three months after a heart attack, advocated building up in stages after that from 1.25 mg. to 5 mg. a day. Los Angeles' Dr. Jessie Marmorston reported that she got good results (TIME, June 15, 1959) without ever going over 1.25 mg., and that on this small dose her patients are not noticeably feminized. But Dr. Stamler insisted that bigger doses are necessary, and some feminizing is unfortunately unavoidable...
...answer to both questions is yes, according to investigators at the University of Southern California School of Medicine. Red-haired and vivacious at 60, Dr. Jessie Marmorston reported last week on 174 women (many over 70) who had had one or more heart attacks-in nearly every case a coronary occlusion. She divided them into two equal groups, matched as precisely as possible for age and severity of symptoms. One-half got a small daily dose (ten-millionths of a gram) of estrogen, the rest got none. After three years, more than twice as many in the nonestrogen group...
...Oliver Kuzma, working with Dr. Marmorston and her group, reported parallel evidence from a group of 109 men who got a slightly larger but virtually nonfeminizing dose of estrogen. In addition to an encouraging trend in the male death rate, Dr. Kuzma reported that in most cases the levels of cholesterol and other fat fractions circulating in the blood of heart-attack victims returned closer to normal, with no untoward feminizing effects. And Dr. Kuzma found that increasing the dosage, to the point where feminization was unmistakable, conferred no added advantage...
Though chemists are eagerly seeking a synthetic that will have the advantages but not the feminizing disadvantages of the natural estrogen, Drs. Marmorston and Kuzma see no need to wait for this millennium. They feel much good can be done with the currently available estrogens (marketed under different names by a dozen U.S. drug companies). Even on prescription, the low-dosage tablets should not cost more than a nickel...
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