Word: marrow
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Dates: during 1950-1959
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...Forced to transplant a kidney from a child with no genetic relation to Mrs. Lowman, physicians had the problem of countering antibodies that would have rejected the alien organ. For the first time, they tried to solve it by destroying the antibodies' source, the patient's bone marrow, with X rays. Though new bone marrow was injected, it failed to generate enough white corpuscles to prevent the spread of infection. But physicians consider the attempt highly valuable toward perfection of future kidney transplants...
...desperate case of Mrs. Lowman, doctors operated for the first time on a new theory. Since antibodies are born in blood cells produced in the bone marrow, it might be possible to curb them by destroying the marrow itself. No mechanism would then remain to reject a transplanted tissue. New bone marrow, from several donors to minimize antibody hostility, could then be injected intravenously...
Taking Over. For three hours under an X-ray machine. Mrs. Lowman was subjected to massive radiation that killed all her bone marrow. Her white blood corpuscle count fell from the normal 5,000 per cubic centimeter to zero. Then a kidney from a four-year-old girl (whose treatment for hydrocephalus required kidney removal) was transplanted to Mrs. Lowman. The Boston surgeons attached it to the femoral arteries and veins below the groin in her right thigh. She received a dozen marrow transfusions before and during the operation, mainly from her brothers. With her count of disease-fighting white...
...professor of biological chemistry at Washington University's School of Medicine (since 1947), winner (with her biochemist husband Carl) of a Nobel Prize in medicine in 1947 for studies of the body's uses of starches and sugars; of complications of myelofibrosis, a disease of the bone marrow; in St. Louis...
...start the story, the unmistakable voice soared like a chord out of the TV screen. In the end Narrator Walter Cronkite intoned: "This was the man . . . When will there be another like him?" The marrow in between was a combination of film clips, photographs and dialogue lovingly composed by Producer Burton Benjamin, Associate Producer Isaac Kleinerman and Writer John Davenport into a Concerto for Orchestra and One Man. Some rare scenes: a Soviet film of Lenin; an impatient Churchill pouncing up the gangplank of a World War II warship; a silently terrible shot of the British wreckage at Dunkirk...