Word: marrow
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Dates: during 1980-1989
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...payoff from it may come a bit sooner. In that experiment, a team of scienlists led by Martin Cline and Winston Salser isolated genes that help produce an enzyme resistant to methotrexate, a drug used to treat cancer. The researchers added the genes to cell cultures of mouse bone marrow. The cells that picked up the foreign material, along with cells that had been incubated with genes that do not confer resistance, were then injected into mice whose own bone marrow had been destroyed. To see if the drug-resistance genes were working, the animals were given methotrexate. Tests after...
...create human hybridomas. They took spleen cells from victims of Hodgkin's disease, a form of cancer in which the spleen is usually removed during treatment. The cells had already been exposed to the chemical dinitrochlorobenzene and were making antibodies. These cells were then fused with cancerous bone-marrow cells, yielding hybrid cells that could churn out the antibody...
DIED. Teddy DeVita, 17, whose struggle to conquer a rare bone marrow disease in an 8-ft. by 9-ft., germ-free isolation room at the National Cancer Institute won him wide attention as the courageous "boy in the glass cage"; of complications from repeated blood transfusions; in Bethesda, Md. Teddy was nine when he developed aplastic anemia, which destroys the body's ability to fight off any infection. His life in his sterile sanctuary, portrayed by John Travolta in a 1976 TV film, was poignant: he sometimes threatened to walk out to virtually certain death, but mostly...
...urban dwellers of developing and dying from six types of cancer. Analyzing the death certificates of more than 20,000 white male lowans, Dr. Leon Burmeister and his colleagues found that prostate, stomach, lymph gland and lip cancer, as well as leukemia and multiple myeloma (a form of bone marrow cancer), occurred up to three times more frequently among farmers...
...looked promising. Of 16 patients with breast cancer that had metastasized (spread to other parts of the body), seven cases showed noticeable improvement, five of them enough to be classified as partial remissions. Tumors shrank substantially in three of eleven patients with multiple myeloma, a cancer of the bone marrow. Though it is too early in the treatment of patients with lymphoma (a cancer of the lymph system) or melanoma (skin cancer) to assess the effect of the drug, the attending doctors see encouraging signs. Discussing the early results, Frank Rauscher, head of research at the A.C.S., was emphatic. Said...