Word: marrow
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...transferring some of the donor’s bone marrow along with the organs, two Medical School researchers have found a way to fool immune cells into accepting foreign tissue as well. Four of the five study’s subjects received successful transplants...
...which normally patrol the body looking for foreign invaders like bacteria, viruses and tissues from outside donors. Several days before the transplant surgery, Sachs' team used drugs that target and eliminate these cells to wipe the immune slate clean. Then the team transplanted the kidney along with donor bone-marrow cells. What happened next was surprising: the bone marrow rebuilt the immune system but this time as a chimera?a hybrid of both the donated organ's cells and the body's own. The donated organ could then be accepted instead of rejected...
...original version of this article mistakenly reported that surgeons transplanted a donated kidney along with bone-marrow cells that had been harvested from the patient. In fact, the bone-marrow cells also came from the donor...
...multistep therapy requires doctors to extract bone-marrow stem cells from breast-cancer patients prior to surgery. After the tumor-removal operation, patients are exposed to brutal doses of chemotherapy, then re-infused with their stem cells, which restore immune cells destroyed by the chemotherapy. But ultrahigh doses of chemo are extremely toxic, and in fact, some of the 20,000 women who have received the treatment in the U.S. have died from the toxicity...
Scientists have known for decades that stem cells sometimes migrate from the bone marrow into the bloodstream. But they have not yet understood the “meaning and consequences” of this phenomenon until now, von Andrian said...